Life Diagnostics生產(chǎn)ELISA試劑盒、SPARCL™試劑盒、用于臨床前研究和獸醫(yī)診斷的純化生物標(biāo)志物和抗體。Life Diagnostics的專業(yè)領(lǐng)域包括心血管、急性期、免疫毒性和免疫學(xué)生物標(biāo)志物，涉及的物種包括老鼠、大鼠、兔子、貓、狗、豬、牛、猴子和雞。此外，Life Diagnostics還開(kāi)發(fā)了抗PEG單克隆抗體和ELISA試劑盒，用于檢測(cè)PEG、mPEG化蛋白和抗PEG抗體。Life Diagnostics公司一直致力于為客戶提供高質(zhì)量的產(chǎn)品和優(yōu)質(zhì)的服務(wù)，贏得了廣泛的贊譽(yù)和信任。
主要產(chǎn)品線
一、SPARCL™試劑盒
SPARCL™（空間近距分析試劑捕獲發(fā)光）檢測(cè)使用兩種特定的抗體；一種與HRP結(jié)合，另一種與二氫化吖啶結(jié)合，一種化學(xué)發(fā)光底物。當(dāng)HRP和二氫化吖啶結(jié)合的抗體與它們的靶生物標(biāo)志物結(jié)合時(shí)，加入過(guò)氧化氫（觸發(fā)溶液）后，HRP催化氧化鄰近二氫化吖啶分子，導(dǎo)致與生物標(biāo)志物濃度成比例的化學(xué)發(fā)光。遠(yuǎn)離HRP的二氫化吖啶分子不被氧化，因此不產(chǎn)生發(fā)光。這一原理可以開(kāi)發(fā)一系列快速敏感的均相免疫分析方法。
典型的SPARCL™檢測(cè)不需要洗滌步驟，只需一次孵育，從開(kāi)始到結(jié)束大約需要45分鐘。而ELISA需要1-4次孵育，1-3次洗滌步驟，需要2-4+小時(shí)。SPARCL™試劑盒需要一個(gè)能夠同時(shí)加樣和測(cè)量的光度計(jì)。Life Diagnostics提供一系列的SPARCL™檢測(cè)試劑盒。
SPARCL™—ELISA的優(yōu)秀替代品
–簡(jiǎn)單發(fā)光免疫測(cè)定
–單次培養(yǎng)30分鐘
–無(wú)清洗步驟
–高靈敏度
–高吞吐量
參考文獻(xiàn)
1. Baka R, et al. Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic sezures. J Proteomics 231:1039777 (2021)
2. Kules J, et al. The plasma proteome and the acute phase protein response in canine pyometra. J Proteomics 223:103817 (2020)
3. Liu M, et al. Cardiovascular-renal axis disorder and the acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy. J Vet Intern Med. 34(3):1078-1090 (2020)
4. Dalanezi FM, et al. Concentrations of acute phase proteins in milk from cows with clinical mastitis caused by different pathogens. Pathogens 9(9):706 (2020)
5. Boulay I, et.al. SPARCL™: Use of a novel technology in validation of a Non-human primate and rat cardiac troponin-I assay in serum. CiToxLAB, 2016
6. Boulay I, et.al. SPARCL™: Use of a Novel Technology in Validation of a Non-Human Primate C-Reactive Protein Assay in Serum. CiToxLAB. 2016
部分產(chǎn)品信息
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 |
AFP-SP-4 | Dog Alpha-fetoprotein | 96-well |
AGP-SP-11 | Cow AGP | 96-well |
AGP-SP-2 | Rat AGP | 96-well |
AGP-SP-5 | Chicken AGP | 96-well |
AGP-SP-8 | Cat AGP | 96-well |
CER-SP-4 | Dog Ceruloplasmin | 96-well |
CYSC-SP-2 | Rat Cystatin-C | 96-well |
HFABP-SP-20 | Human H-FABP | 96-well |
IGG1-SP-1 | Mouse IgG1 | 96-well |
IGG-SP-1 | Mouse IgG | 96-well |
MPEG-SP | mPEG | 96-well |
MYO-SP-1 | Mouse Myoglobin | 96-well |
MYO-SP-2 | Rat Myoglobin | 96-well |
MYO-SP-3 | Monkey Myoglobin | 96-well |
PEG-SP | PEG | 96-well |
TK1-SP-20 | Human Thymidine Kinase 1 | 96-well |
二、ELISA試劑盒
抗KLH、抗SRBC、抗破傷風(fēng)毒素、抗DNP和抗TNP的IgM和IgG被用作免疫毒性的生物標(biāo)志物。Life Diagnostics為小鼠、大鼠、雞、猴子和人類生產(chǎn)這些生物標(biāo)志物的ELISA試劑盒。
使用Life Diagnostics ELISA試劑盒發(fā)表的部分文獻(xiàn)
1. Lo J, et al. Immature dendritic cell therapy confers durable immune modulation in an antigen-dependent and antigen-independent manner in nonobese diabetic mice. Journal of Immunology Research. Volume 2018 Article ID 5463879 (2108) [Mouse anti-KLH IgG & IgM]
2. Ksiazek A and Konarzewski M. Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR). Journal of Experimental Biology. 219:1542-1551 (2016) [Mouse anti-KLH IgG & IgM]
3. Tan X, et al. Immunotoxicological evaluation of genetically modified rice expressing Cry1Ab/AcProtein (TT51-1) by a 6-month feeding study on cynomolgus monkeys. PLoSONE 11(9):e0163879.doi:10.1371/journal.pone.0163879 (2016) [Monkey anti-KLH IgG & IgM]
4. Ma H, Wan S, and Xia C-Q. Immunosuppressive CD11b+Ly6Chi monocytes in pristane-induced lupus mouse model. Journal of Leukocyte Biology 99:1121 (2016). [Mouse anti-KLH IgG]
5. Nixon AE, et al. Fully human monoclonal antibody inhibitors of the neonatal Fc receptor reduce circulating IgG in non-human primates. Frontiers in Immunology. Volume 6, Article 176. (2015) [Monkey anti-tetanus toxoid & anti-KLH IgG & IgM]
6. Bernett MJ, et al. Immune suppression in cynomolgus monkeys by XPro9523. (2013) https://doi.org/10.4161/mabs.23976 [Monkey anti-KLH IgG & IgM]
7. Nain S and Smits JEG. Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats. Environmental Toxicology. (2010) http://onlinelibrary.wiley.com/doi/10.1002/tox.20635/abstract [Rat anti-KLH IgG & IgM]
8. Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH and Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207(5):933-942 (2011) [Mouse anti-SRBC IgG & IgM] http://jem.rupress.org/content/207/5/933.full.pdf+html
9. Schaffer BS, Grayson MH and Wortham JM, et al. Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol. Cancer Ther. 9:2354-2364 (2010) [Mouse anti-KLH IgG & IgM] http://mct.aacrjournals.org/content/9/8/2354.full.pdf+html
10. Efanov A, Zanesi N, NazaryanN, Santanam U, Palmarchuck A Croce CM and Pekarsky Y. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 24:970-975 (2010) [Mouse anti-SRBC IgM]
部分產(chǎn)品信息
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 |
KLHG-1 | Mouse Anti-KLH IgG ELISA | 96-well |
KLHM-1 | Mouse Anti-KLH IgM ELISA | 96-well |
KLHG-20 | Human Anti-KLH IgG ELISA | 96-well |
KLHM-20 | Human Anti-KLH IgM ELISA | 96-well |
TTG-2 | Rat Anti-Tetanus Toxoid IgG ELISA | 96-well |
TTM-2 | Rat Anti-Tetanus Toxoid IgM ELISA | 96-well |
DNPG-1 | Mouse Anti-DNP IgG ELISA | 96-well |
DNPM-1 | Mouse Anti-DNP IgM ELISA | 96-well |
TNPG-1 | Mouse Anti-TNP IgG ELISA | 96-well |
TNPM-1 | Mouse Anti-TNP IgM ELISA | 96-well |
SRBCG-5 | Chicken Anti-SRBC IgG ELISA | 96-well |
SRBCM-5 | Chicken Anti-SRBC IgM ELISA | 96-well |
三、蛋白
Life Diagnostics提供alpha-1-acid glycoprotein、CRP、haptoglobin、SAA等急性期生物標(biāo)志物、troponin-I、myoglobin、FABP等心血管生物標(biāo)志物、免疫球蛋白、Haptoglobin、Gc-Globulin肝臟生物標(biāo)志物、Troponin-I骨骼肌生物標(biāo)志物等系列產(chǎn)品，用于臨床前研究研究和診斷分析開(kāi)發(fā)。
部分產(chǎn)品信息
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 |
8340 | Bovine (Cow) alpha-1-acid glycoprotein | 1 mg |
9060 | CAT LRG1 | 100 μg |
8160 | Cat Haptoglobin | 1 mg |
EXFABP-5-0.05 | Chicken EX-FABP | 0.05 mg |
9005 | Dog Serum Amyloid A (SAA) | 0.1 mg |
8356 | Rabbit a-1-Acid glycoprotein | 0.1 mg |
20110 | Mouse L-FABP | 0.1 mg |
20220 | Rat Gc-Globulin | 0.1 mg |
HAPT-2 | Rat Haptoglobin | 1 mg |
3610 | Chicken Skeletal Muscle Troponin-I | 0.1 mg |
3410 | Sheep Skeletal Muscle Troponin-I | 0.1 mg |
四、PEG相關(guān)產(chǎn)品
聚乙二醇（PEG）鏈連接到治療性抗體和酶上，可以增加生物制劑的循環(huán)半衰期。Life Diagnostics生產(chǎn)單克隆抗體和ELISA試劑盒，用于檢測(cè)PEG和甲氧基-PEG化蛋白。此外，Life Diagnostics還提供用于檢測(cè)小鼠、大鼠和猴子體內(nèi)抗PEG IgG和IgM的ELISA試劑盒。
部分產(chǎn)品信息
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 |
5D6-3 | Anti-methoxy-PEG Monoclonal, Clone 5D6-3 | 100 μg |
1D9-6 | Anti-PEG Monoclonal, Clone 1D9-6 | 100 μg |
PEGPAB-01 | Anti-PEG Rabbit Polyclonal IgG Antibody | 100 μg |
PEGM-3 | Monkey Anti-PEG IgM ELISA | 96-well |
PEGM-20 | Human Anti-PEG IgM ELISA | 96-well |
PEGM-10 | Rabbit Anti-PEG IgM ELISA | 96-well |
PEGG-3 | Monkey Anti-PEG IgG ELISA | 96-well |
PEGG-20 | Human Anti-PEG IgG ELISA | 96-well |
PEGG-10 | Rabbit Anti-PEG IgG ELISA | 96-well |
PEGM-2 | Rat Anti-PEG IgM ELISA | 96-well |
PEGM-1 | Mouse Anti-PEG IgM ELISA | 96-well |
PBSA-00 | Multi PEGylated BSA | 1 mg |
PBSA-01P | Mono-PEGylated BSA (pentanoic acid-PEG, 20 kDa) | 100 μg |
五、抗體
Life Diagnostics提供alpha-1-acid glycoprotein等急性期生物標(biāo)志物、troponin-I、myoglobin、FABP等心血管生物標(biāo)志物、免疫球蛋白、Haptoglobin、Gc-Globulin肝臟生物標(biāo)志物、Troponin-I骨骼肌生物標(biāo)志物等蛋白抗體以及一系列二抗產(chǎn)品。
部分產(chǎn)品信息
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 |
IGE-4-13H5 | Anti-Dog IgE Monoclonal | 1 mg |
IGE-4-4D1 | Anti-Dog IgE Monoclonal | 1 mg |
IGM-23-12B9 | Anti-Trout IgM Monoclonal | 1 mg |
IGM-23-2E7 | Anti-Trout IgM Monoclonal | 1 mg |
10C2-9 | Monoclonal Anti Monkey IgG | 1 mg |
6D11-2 | Monoclonal Anti Monkey IgG | 1 mg |
2C11-1-5 | Monoclonal Anti Monkey IgM | 1 mg |
7E8-1-13 | Monoclonal Anti Monkey IgM | 1 mg |
AGP-08-4F57 | Anti-cat alpha-1-acid glycoprotein | 1 mg |
下圖為Life Diagnostics公司授權(quán)上海起發(fā)在中國(guó)區(qū)域的代理的授權(quán)書(shū)。
Life Diagnostics熱賣(mài)產(chǎn)品
貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 | 品牌 |
CRP-3 | Monkey C-Reactive Protein (CRP) ELISA kit | 96 well | Life Diagnostics |
KLHM-3 | Monkey Anti-KLH IgM ELISA kit | 96 well | Life Diagnostics |
KLHG-3-INT | Monkey Anti-KLH IgG ELISA kit for export | 96 well | Life Diagnostics |
KLHM-2 | RAT ANTI-KLH IGM ELISA | 96 well | Life Diagnostics |
KLHG-2 | Rat Anti-KLH IgG ELISA | 96 well | Life Diagnostics |
1D9-6/MG | ANTI-PEG MONOCLONAL, CLONE 1D9-6 | 0.1mg | Life Diagnostics |
PEGG-20 | HUMAN ANTI-PEG IGG ELISA | 96 well | Life Diagnostics |
IGG-20 | Human IgG ELISA | 96 well | Life Diagnostics |
5H4-2-1mg | ANTI-METHOXY PEG | 1 mg | Life Diagnostics |
1D9-6-1mg | ANTI-PEG MONOCLONAL, CLONE | 1 mg | Life Diagnostics |
PBSA-00 | Multi PEGylated BSA - BSA with multiple covalently attached 20 kDa mPEG chains | 1 mg | Life Diagnostics |
PBAS-00-550-1mg | Multi PEGylated BSA | 1 mg | Life Diagnostics |
PBAS-00-550-10mg | Multi PEGylated BSA | 10 mg | Life Diagnostics |
5D6-3-0.1mg | ANTI-METHOXY PEG | 0.1 mg | Life Diagnostics |
KLHM-20 | HUMAN ANTI-KLH IGM ELISA | 96 well | Life Diagnostics |
5D6-3-1mg | ANTI-METHOXY PEG | 1 mg | Life Diagnostics |
5H4-2-0.1mg | ANTI-METHOXY PEG | 0.1 mg | Life Diagnostics |
KLHG-20 | Human Anti-KLH IgG ELISA | 96 well | Life Diagnostics |
CLUS-1 | Mouse Clusterin ELISA kit | 96 well | Life Diagnostics |
8511-0.1mg | Rat a-2-Macroglobulin | 0.1 mg | Life Diagnostics |
IGE-3 | MONKEY IGE ELISA | 96 well | Life Diagnostics |
IGE-2 | Rat IgE | 96 well | Life Diagnostics |
CTNI-3-US | MONKEY CARDIAC TROPONIN-I ELISA | 96 well | Life Diagnostics |
CTNI-1-US | Mouse cTnI, (serum/plasma) ELISA kit | 96 well | Life Diagnostics |
CTNI-1-HS | Mouse cTnI (serum) ELISA kit | 96 well | Life Diagnostics |
crp-sp-20 | HUMAN CRP SPARCL™ ASSAY | 96 well | Life Diagnostics |
CRP-2 | Rat C-Reactive Protein (CRP) ELISA kit | 96 well | Life Diagnostics |
8511-PT1MG | RAT ALPHA-2-MACROGLOBULIN, 8511 | 0.1 mg | Life Diagnostics |
作為Life Diagnostics在中國(guó)區(qū)域的總代理，上海起發(fā)將為中國(guó)客戶提供全面的Life Diagnostics產(chǎn)品。歡迎大家隨時(shí)聯(lián)系我們?。。?/span>
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